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Treatment of periodic leg movement disorder and restless leg syndrome with talipexole
Author(s) -
Inoue Yuichi,
Mitani Hideaki,
Nanba Kazuyoshi,
Kawahara Ryuzo
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00522.x
Subject(s) - restless legs syndrome , bedtime , physical medicine and rehabilitation , psychology , polysomnography , physical therapy , medicine , sleep (system call) , insomnia , psychiatry , electroencephalography , computer science , operating system
In order to investigate the bedtime dose of talipexole, a D 2 and α 2 stimulant, on patients with periodic leg movement disorder (PLMD) and restless leg syndrome (RLS), we made a comparison of polysomnographic findings and subjective symptom ratings before and during 4 weeks of the treatment on five cases with RLS and PLMD. A significant decrease in both the frequencies of periodic leg movements and subjective symptom ratings and significant improvement of sleep composition were recognized during the treatment. We speculate that the combination of the agonistic action of D 2 and α 2 receptor with the drug might not only suppress PLMD and RLS but also improve sleep quality.