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Effects of sleep deprivation: The phosphorus metabolism in the human brain measured by 31 P‐magnetic resonance spectroscopy
Author(s) -
Murashita Jun,
Yamada Naoto,
Kato Tadafumi,
Tazaki Masayoshi,
Kato Nobumasa
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00487.x
Subject(s) - metabolism , phospholipid , sleep deprivation , phosphorus , endocrinology , medicine , phosphomonoesters , intracellular ph , intracellular , chemistry , high energy phosphate , nuclear magnetic resonance spectroscopy , energy metabolism , antidepressant , depression (economics) , lipid metabolism , phosphate , inorganic phosphate , biochemistry , phosphocreatine , hippocampus , membrane , circadian rhythm , organic chemistry , economics , macroeconomics
Sleep deprivation (SD) has an antidepressant effect in some, but not all, patients with depression, although its biological mechanisms have not yet been characterized. We previously reported altered brain phosphorus metabolism measured by phosphorus‐31 magnetic resonance spectroscopy ( 31 P‐MRS) in patients with bipolar depression. We preliminarily examined effects of SD on phosphorus metabolism in the frontal lobes of 15 normal subjects using 31 P‐MRS. No significant differences of membrane phospholipid metabolism, high‐energy phosphate metabolism and intracellular pH were found between before and after SD in these subjects. Further studies will be necessary to elucidate the physiological mechanism of SD for depressive patients.