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Severe chronic active giftein‐Barr virus infection accompanied by virus‐associated hemophagocytic syndrome, cerebellar ataxia and encephalitis
Author(s) -
YAMASHITA SHUICHI,
MURAKAMI CHISA,
IZUMI YOICHIRO,
SAWADA HITOSHI,
YAMAZAKI YOSHIHIRO,
YOKOTA TADAAKI,
MATSUMOTO NOBUHIRO,
MATSUKURA SHIGERU
Publication year - 1998
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1998.00406.x
Subject(s) - medicine , encephalitis , ataxia , prednisolone , immunology , epstein–barr virus infection , virus , pathology , virology , epstein–barr virus , psychiatry
We present a rare case of chronic active giftein‐Barr virus (EBV) infection showing various clinical outcomes. A 26‐year‐old man was admitted to our hospital due to persistent fever and dyspnea. Serologic response of the patient to EBV indicated chronic active infection. He showed pleuritis, parotitis, chronic hepatic dysfunction, disseminated intravascular coagulation, virus associated hemophaghocytic syndrome, acute rhabdomyolysis, acute renal failure, acute cerebellar ataxia, encephalitis and multiple brain abscesses. None of acyclovir, gancyclovir, prednisolone or interleukin‐2 was effectual to abolish those abnormalities. This is the first report of transient cerebellar ataxia which aggravated to panencephalitis associated with chronic EBV infection.