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Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects
Author(s) -
YAMADERA HIROSHI,
NAKAMURA SHUICHI,
SUZUKI HIDEAKI,
ENDO SHUNKICHI
Publication year - 1998
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1998.00403.x
Subject(s) - trazodone , imipramine , polysomnography , placebo , anesthesia , slow wave sleep , sleep (system call) , medicine , psychology , hydrochloride , electroencephalography , psychiatry , antidepressant , chemistry , apnea , alternative medicine , organic chemistry , pathology , computer science , hippocampus , operating system
Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.