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An autopsied case of Creutzfeldt‐Jakob disease with the lateral geniculate body lesion showing antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses
Author(s) -
Aoki Tatsuyuki,
Kobayashi Katsuji,
Jibiki Itsuki,
Muramori Fumihiko,
Hayashi Masahiro,
Miyazu Kenji,
Kobayashi Eiji,
Koshino Yoshifumi,
Yamaguchi Nariyoshi
Publication year - 1998
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1998.00390.x
Subject(s) - lesion , pupillary light reflex , geniculate body , pupillary reflex , superior colliculus , occipital lobe , electroencephalography , medicine , white matter , reflex , superior colliculi , geniculate , neuroscience , pupil , pathology , anatomy , visual system , psychology , retina , visual cortex , magnetic resonance imaging , radiology , nucleus
We reported an necropsy finding of a patient with Creutzfeldt‐Jakob disease (CJD) who showed photo‐stimulated giant spikes that simultaneously suppressed periodic synchronous discharges (PSD) and the loss of pupillary light reflex during the course of the illness. The necropsy revealed extensive gray and white matter lesions, and both the lateral geniculate body (LGB) and pregeniculate body were primarily affected. The superior colliculus, optic nerve and tracts were not affected. The cerebral cortices particularly of the occipital lobe were severely damaged. The Gennari line, however, was spared from lesion. The primary involvement of the LGB has been reported infrequently in CJD, however, it appears to be associated with the unusual electroencephlograph (EEG) feature of the present case. The pregeniculate lesion contributed to the loss of pupillary reflex. This finding indicates that the visual pathway may be involved in the mechanism of the generation of PSD in CJD.