Premium
Meaning of retrograde phenotypic change of mesangial cells in IgA nephropathy
Author(s) -
Shigematsu Hidekazu,
Kaneko Yoko,
Zhang Lianshan,
Nakazawa Koh
Publication year - 2002
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1046/j.1440-1797.7.s3.8.x
Subject(s) - medicine , maldevelopment , nephropathy , phenotype , pathology , immunology , endocrinology , gene , biology , anatomy , genetics , diabetes mellitus
SUMMARY:Mesangial cells show phenotypic changes such as that of glomerular differentiation at the fetal stage in various nephropathies, including IgA nephropathy. Such a process seems necessary for reparative or regenerative reactions in post‐inflammatory or post‐injury glomerular tissues, particularly for the rearrangement of glomerular capillary networks. Glomerular sclerosis may be the end result of failure or maldevelopment of this phenotypic glomerular transformation.