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Role of transforming growth factor beta in peritoneal fibrosis
Author(s) -
ALJAYYOUSI Reem H,
MEDCALF James F,
HARRIS Kevin PG
Publication year - 2002
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1046/j.1440-1797.2002.00116.x
Subject(s) - mesothelial cell , medicine , peritoneal dialysis , peritoneum , transforming growth factor , fibrosis , transforming growth factor beta , cytokine , mesothelium , pathogenesis , peritoneal cavity , pathology , immunology , anatomy
SUMMARY: Technique survival of peritoneal dialysis is seriously limited by the development of peritoneal fibrosis. the mesothelial cell layer lining the peritoneum is important in the pathogenesis of peritoneal fibrosis. Mesothelial cells are able to produce transforming growth factor beta (TGF‐β), and respond to stimulation by this cytokine. In this review, we will detail the evidence available so far for the role of the complex interaction between TGF‐β and mesothelial cells in the development of peritoneal fibrosis.