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Renal haemodynamic characteristics and their correlation with renal pathology in patients with systemic lupus erythematosus
Author(s) -
Nakano Masaaki,
Ueno Mitsuhiro,
Hasegawa Hisashi,
Kuroda Takeshi,
Ito Satoshi,
Arakawa Masaaki,
Gejyo Fumitake
Publication year - 2001
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1046/j.1440-1797.2001.00034.x
Subject(s) - medicine , lupus nephritis , renal function , renal biopsy , effective renal plasma flow , filtration fraction , renal blood flow , renal pathology , hemodynamics , kidney , urology , systemic lupus erythematosus , gastroenterology , pathology , disease
SUMMARY: To clarify the characteristics of renal haemodynamics and their correlation with renal pathology in patients with systemic lupus erythematosus (SLE), renal function and renal biopsy findings from 101 SLE patients were analysed retrospectively. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were examined simultaneously. Filtration fraction (FF) was calculated from the values obtained for GFR and RPF (GFR/RPF). The GFR was low in one‐third and within normal limits in two‐thirds of class IV patients with lupus nephritis (LN). In contrast, high RPF was observed in half of class IV patients. As a result, over 70% of class IV patients possessed a very low FF (less than 15%). The sensitivity of very low FF for class IV LN was significantly higher than that of low GFR. In conclusion, low FF was frequently recognized, especially in patients with diffuse proliferative LN. Decreased FF was a highly sensitive indicator of diffuse proliferative LN. Thus, determination of renal haemodynamics, including FF, may be a useful clinical parameter for evaluating renal involvement in patients with SLE.