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Lipid risk factors for atherosclerotic carotid artery disease in patients on continuous ambulatory peritoneal dialysis
Author(s) -
YORIOKA Noriaki,
TANIGUCHI Yoshihiko,
ITO Takafumi,
Chang SHAO Jin,
MASAKI Takao,
YAMASHITA Kazuomi,
YAMAMOTO Maki,
YAMAKIDO Michio
Publication year - 1998
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1046/j.1440-1797.1998.d01-20.x
Subject(s) - medicine , continuous ambulatory peritoneal dialysis , apolipoprotein b , peritoneal dialysis , cardiology , ambulatory , lipid metabolism , cholesterol , carotid arteries , risk factor , gastroenterology , endocrinology
We investigated the relationship between abnormalities of lipid metabolism and carotid atherosclerosis in 20 patients on continuous ambulatory peritoneal dialysis (11 men and nine women). Carotid ultrasonography was used to determine the combined thickness of the intima and media (I‐M thickness). The apo A‐I/apo B ratio showed a significant negative correlation with I‐M thickness ( P <0.05). In the patients with carotid plaque, the triglycerides (TG) level and the remnant‐like particle cholesterol level (RLP‐C) were significantly higher than in the patients without plaque ( P <0.05), and high density lipoprotein (HDL) cholesterol and the apo AI/apo B ratio were significantly lower than in the patients without plaque ( P <0.05). Moreover, there was a strong relationship between the severity of plaque and TG, the apo AI/apo B ratio, and RLP‐C. Thus, abnormal lipid metabolism may contribute to progressive atherosclerosis, while TG, the apo A‐I/apo B ratio, and RLP‐C levels may be useful indicators of atherosclerotic risk in peritoneal dialysis patients.