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Ultrasound agents may open the blood–brain barrier in rats and aggravate pathologic consequences of experimental head trauma
Author(s) -
Rooker Servan,
Van Reempts Jos,
Van Deuren Bruno,
Borgers Marcel,
Jorens Philippe G.,
Paelinck Bernard P.,
Verlooy Jan
Publication year - 2003
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.2003.00505.x
Subject(s) - medicine , extravasation , blood–brain barrier , brain edema , brain trauma , ultrasound , edema , parenchyma , pathology , anesthesia , head trauma , cerebral edema , traumatic brain injury , surgery , central nervous system , radiology , psychiatry
Unilateral intracarotid injection of contrast agents may considerably destabilize the blood–brain barrier in rats. This leads to vasogenic edema in the ipsilateral hemisphere. Mortality and extravasation increased significantly when administration of these ultrasound contrast agents was followed by mild traumatic brain injury. Direct administration to the cerebral circulation is, therefore, indicative for edema‐related pathology and may amplify the consequences of experimental neurotrauma.