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Creutzfeldt–Jakob disease with florid plaques after cadaveric dura mater graft
Author(s) -
Mochizuki Yoko,
Mizutani Tomohiko,
Tajiri Nobuo,
Oinuma Toshinori,
Nemoto Norimichi,
Kakimi Shigeo,
Kitamoto Tetsuyuki
Publication year - 2003
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.2003.00489.x
Subject(s) - dura mater , creutzfeldt jakob syndrome , medicine , pathology , myoclonus , cadaveric spasm , slow virus , ataxia , anatomy , disease , prion protein , virology , virus , viral disease , psychiatry
A patient with dura‐associated Creutzfeldt‐Jakob disease (D‐CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D‐CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron‐microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D‐CJD may belong to a new subtype of D‐CJD.