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Peripheral primitive neuroectodermal tumor within the spinal epidural space
Author(s) -
IzyckaSwieszewska Ewa,
Stefanowicz Joanna,
DebiecRychter Maria,
Rzepko Robert,
BorowskaLehman Jolanta
Publication year - 2001
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.2001.00387.x
Subject(s) - synaptophysin , pathology , enolase , differential diagnosis , fluorescence in situ hybridization , immunohistochemistry , spinal cord , chromogranin a , medicine , in situ hybridization , biology , anatomy , neuroscience , messenger rna , biochemistry , chromosome , gene
A case of an epidural spinal peripheral primitive neuroectodermal tumor (pPNET) in a 13‐year‐old girl is presented. The tumor was disseminated at the moment of diagnosis, thus only diagnostic oligobiopsy of the epidural mass was performed. Histologically the tumor was composed of small round blue cells. The neoplastic cells expressed MIC2 and features of neural differentiation on immunohistochemical staining (neuron‐specific enolase, synaptophysin and NCAM positivity). Fluorescent in situ hybridization (FISH) analysis was performed for the final diagnosis and the translocation t(11;22)(q24;q12) was detected. The present case emphasizes the usefulness of FISH in differential diagnosis of tumors, especially when only routinely fixed material is available.