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Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases
Author(s) -
Tsuchiya Kuniaki,
Arima Kunimasa,
Fukui Toshiya,
Kuroiwa Toshihiko,
Haga Chie,
Iritani Shuji,
Hirai Shigeo,
Nakano Imaharu,
Takemura Tamiko,
Matsushita Masaaki,
Ikeda Kenji
Publication year - 1999
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.1999.00252.x
Subject(s) - basal ganglia , putamen , pathology , corticobasal degeneration , amygdala , caudate nucleus , autopsy , basal (medicine) , medicine , differential diagnosis , anatomy , pick's disease , disease , degenerative disease , central nervous system , progressive supranuclear palsy , insulin
The distribution of the basal ganglia lesions, including the amygdala, striatum, and pallidum, were investigated neuropathologically in eight Japanese autopsy cases of Pick's disease with Pick bodies. The lesions were classified as mild, moderate or severe. The degree and distribution of basal ganglia lesions in all eight cases were uniform: the amygdala showed severe to moderate lesions, the caudate nucleus and putamen showed moderate to mild lesions, and the pallidum showed mild lesions. Furthermore, the lesions in the amygdala were more prominent in the basolateral group than in the corticomedial group. In Pick's disease with Pick bodies, the degree and distribution of the lesions within the basal ganglia differs from those reported in both ‘Pick's disease without Pick bodies’ and corticobasal degeneration (CBD), in which severe lesions were present in the pallidum. These neuropathological findings may contribute to the morphological differential diagnosis among Pick's disease with Pick bodies, ‘Pick's disease without Pick bodies’, and CBD.