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Is Ihara's genetically epileptic rat an adequate model for studying human temporal lobe epilepsy? Verification of suitability from the clinical and pathomorphological perspectives
Author(s) -
Amano S
Publication year - 1999
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.1999.00231.x
Subject(s) - epilepsy , temporal lobe , animal model , similarity (geometry) , neuroscience , psychology , medicine , computer science , artificial intelligence , image (mathematics)
We developed a novel epileptic mutant with spontaneous generalized tonic clonic convulsions, Ihara's genetically epileptic rat (IGER). Judging from the characteristics of the symptomatology, electroencephalographic correlates, and neuropathological findings, this epileptic mutant can be expected to be a useful model for studying human temporal lobe epilepsy (TLE). Verification of the suit‐ability of IGER as a model for human TLE was carried out from the clinical and pathomorphological perspectives. IGER basically meets the first and the second criteria for an animal model, that is, similarity of symptomatology of the disease in the animal model and humans, and similarity of pathomorphological changes in the lesions of the model and humans. Causative similarity, the third criterion, re‐mains to be established for IGER and human TLE. Judging from the first and second criteria, IGER seems to be a useful tool for studying human TLE.