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The involvement of glial NO synthase/NO in neuronal apoptosis in the brain
Author(s) -
Nomura Yasuyuki
Publication year - 1999
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.1999.00213.x
Subject(s) - nitric oxide synthase , apoptosis , neuroscience , ischemia , biology , nitric oxide , neuronal damage , programmed cell death , microbiology and biotechnology , medicine , neuroprotection , biochemistry , endocrinology
Cerebral ischemia induces a variety of cellular and molecular responses in the brain. Among these responses, glial expression of inducible nitric oxide (NO) synthase (iNOS) and neuronal death are crucial, because these seem to be relevant to serious brain disorders. Therefore, elucidation of the mechanisms of glial iNOS expression and NO‐induced neuronal apoptosis could be important in terms of the pharmacological manipulation of brain in‐farction induced by several stress factors, such as ischemia. The present article reviews the recent findings in cytoche‐mical, cellular and molecular investigations on the cerebral ischemia‐ and bacterial endotoxin (LPS)/IFNγ‐induced iNOS expression and NO‐induced neuronal apoptosis in the brain.