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Thoracic paravertebral ganglioneuroma with high immunohistochemical expression of TrkA
Author(s) -
Nishio Shunji,
Hamada Yasuhiro,
Nakagawara Akira,
Haga Sei,
Fukui Satoshi Suzuki and Masashi
Publication year - 1999
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1046/j.1440-1789.1999.00210.x
Subject(s) - ganglioneuroblastoma , immunohistochemistry , ganglioneuroma , tropomyosin receptor kinase a , histogenesis , enolase , neurofilament , medicine , pathology , neuroblastoma , anatomy , nerve growth factor , receptor , biology , cell culture , genetics
A 21‐year‐old man, who had previously undergone a total resection for a retroperitoneal ganglioneuroblastoma at 7 months of age, was revealed to have a thoracic paravertebral ganglioneuroma, in which immunohistochemical expression of neuron‐specific enolase and neurofilament was noted. Furthermore, immunohistochemical expression of TrkA, which is a high‐affinity receptor for nerve growth factor, was evident. Although the exact histogenesis remains uncertain, TrkA was considered to be involved in the development of this thoracic paravertebral tumor.