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Maternal thyrotoxicosis causing central hypothyroidism in infants
Author(s) -
Lee YS,
Loke KY,
Ng SCY,
Joseph R
Publication year - 2002
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.2002.00741.x
Subject(s) - medicine , central hypothyroidism , pediatrics , pregnancy , thyroid , fetus , congenital hypothyroidism , graves' disease , disease , endocrinology , genetics , biology
: We describe three infants born to mothers with poorly controlled Graves’ disease, who developed transient central hypothyroidism in the immediate postnatal period. Suppression of the fetal pituitary‐thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months postnatally, necessitating treatment to optimise neurodevelopmental outcome.