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Low‐density lipoprotein subclasses in children under 10 years of age
Author(s) -
Steinbeck KS,
Bermingham MA,
Mahajan D,
Baur LA
Publication year - 2001
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.2001.00753.x
Subject(s) - medicine , body mass index , anthropometry , insulin resistance , obesity , leptin , cohort , endocrinology , abdominal obesity , waist , demography , lipoprotein , cholesterol , sociology
Objective : To examine the prevalence of small dense low density lipoprotein (LDL) in a cohort of children under 10 years of age and to investigate the relationship to other biochemical variables and to measures of fatness. A preponderance of small dense LDL (pattern B), is associated with obesity, abdominal fat accumulation, insulin resistance and risk of heart disease in adults. Methodology : LDL peak particle diameter (PPD) was determined by gel electrophoresis in 53 children under 10 years of age and in 65 of their parents: apoproteins A1 and B were determined by turbidimetry. Anthropometric variables, basic lipid profiles, insulin and leptin had been determined previously. Differences between patterns A (large light particles > 25.5 nm diameter) and B were examined by t ‐test, Chi‐square, or Mann–Whitney test. Relationships between the variables were reported as Pearson correlation coefficients. Results : Pattern B (PPD of ≤ 25.5 nm) prevalence was 7.5% in children and 11% in parents (17% in men and 5% in women). Most of the children (86%) who had PPD ≤ 26.0 nm also had parents with PPD in this range. A strong association was found between children’s and mother’s PPD ( r = 0.60, P < 0.001), but this was somewhat less with fathers ( r = 0.40, P = 0.02). Children in the lowest tertile of PPD had a tendency towards a higher body mass index, waist, fat mass and insulin. Conclusions : The prevalence of small dense LDL is lower in children under 10 years of age than in their parents; fathers had a higher prevalence of pattern B than mothers and there is some evidence of a familial effect in the inheritance of pattern B.