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Effect of cisapride on gastric emptying in premature infants with feed intolerance
Author(s) -
Barnett CP,
Omari T,
Davidson GP,
Goodchild L,
Lontis R,
Dent J,
Haslam RR
Publication year - 2001
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.2001.00705.x
Subject(s) - cisapride , medicine , gastric emptying , placebo , gastroenterology , reflux , prokinetic agent , crossover study , breath test , metoclopramide , randomization , gestational age , stomach , vomiting , randomized controlled trial , pregnancy , helicobacter pylori , disease , alternative medicine , pathology , biology , genetics
Objective : To assess the effect of cisapride on gastric emptying and gastro‐oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance. Methods : Sixteen preterm infants (gestational age 24–35 weeks) with feed intolerance were enrolled in the study. Infants were randomized to receive 7 days of cisapride 0.2 mg/kg four times a day, immediately followed by 7 days of placebo or vice versa. Gastric emptying was measured using the [ 13 C]‐octanoic acid breath test prior to study entry and repeated on day 5, 6 or 7 after randomization and 5, 6 or 7 days after crossover. The symptoms of GOR were monitored during the study period using a standardized reflux chart. Weight was recorded daily. Results : There was no change in gastric emptying in infants prescribed cisapride (gastric half‐emptying time (t 1/2 ) 31.9 ± 4.7 vs 34.2 ± 3.9 min for placebo vs cisapride, respectively; P = 0.65). Infants on cisapride had slower growth and there was no change in reflux symptoms. Conclusions : The use of cisapride in preterm infants with feed intolerance cannot be recommended.