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The changing pattern of diagnosis of infantile cholestasis
Author(s) -
Stormon MO,
Dorney SFA,
Kamath KR,
O'Loughlin EV,
Gaskin KJ
Publication year - 2001
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.2001.00613.x
Subject(s) - medicine , cholestasis , neonatal cholestasis , pediatrics , etiology , parenteral nutrition , disease , liver disease , tertiary referral hospital , referral , alagille syndrome , medical record , hypoplasia , biliary atresia , retrospective cohort study , liver transplantation , family medicine , transplantation
Objective : Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12‐year period (1985–96). Methodology : Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records. Results : There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%. Conclusions : This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease.