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Hepatic glycogenosis: Reversible hepatomegaly in type 1 diabetes
Author(s) -
Munns Cfj,
McCrossin Rb,
Thomsett Mj,
Batch J
Publication year - 2000
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.2000.00547.x
Subject(s) - medicine , gastroenterology , diabetes mellitus , type 1 diabetes , elevated transaminases , nausea , steatosis , liver biopsy , transaminase , alanine transaminase , abdominal pain , organomegaly , type 2 diabetes , vomiting , liver function tests , endocrinology , biopsy , polyneuropathy , biochemistry , chemistry , enzyme
Objective : To describe the aetiology, clinical features and appropriate treatment for hepatic glycogenosis in poorly controlled type 1 diabetes. Methods : A review of three adolescents with poor diabetes control, hepatomegaly and elevated serum liver transaminase concentrations. Results : Symptoms included abdominal pain, anorexia, nausea and vomiting. All had tender hepatomegaly; two had splenomegaly. Liver biopsy was performed on two patients. Histology revealed hepatic glycogenosis in both; one also demonstrated macrovesicular steatosis. With improved glycaemic control, all three showed resolution of their symptoms, organomegaly and elevated serum liver transaminase concentrations. Conclusions : Insulin‐reversible hepatic glycogenosis is the most common cause of hepatomegaly and raised serum liver transaminase concentrations in children and adolescents with type 1 diabetes. Having excluded other causes of hepatic dysfunction, a 4 week therapeutic trial of improved glycaemic control is recommended prior to more invasive investigations.