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The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye’s syndrome
Author(s) -
Ku ASW,
Chan LTW
Publication year - 1999
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.1999.t01-1-00329.x
Subject(s) - medicine , reye's syndrome , influenza a virus subtype h5n1 , respiratory distress , pneumonia , reye syndrome , transmission and infection of h5n1 , aspirin , influenza a virus , respiratory system , virus , intensive care medicine , pediatrics , immunology , surgery , avian influenza virus
Avian influenza virus was not known to cause systemic infection in humans before. We report a 3‐year‐old boy with good past health who developed pneumonia caused by H5N1 avian influenza A virus (A/Hong Kong/156/97). The virus was isolated from a tracheal aspirate. There were complications of Reye’s syndrome, adult respiratory distress syndrome, and multiple organ system failure. He had a history of receiving aspirin. His adult respiratory distress syndrome did not respond to endotracheal surfactant replacement therapy. He died 6 days after admission. Clinicians should be alert to the importance of a new human influenza strain.