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Sepsis, severe sepsis and septic shock in paediatric multiple organ dysfunction syndrome
Author(s) -
Goh AYT,
Chan PWK,
Lum LCS
Publication year - 1999
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.1999.355409.x
Subject(s) - medicine , sepsis , septic shock , organ dysfunction , multiple organ dysfunction syndrome , incidence (geometry) , severity of illness , shock (circulatory) , intensive care unit , intensive care medicine , physics , optics
Objectives: To determine the association between severity of sepsis with outcome and severity of illness in children with multiple organ dysfunction syndrome (MODS). Materials: Four hundred and ninety‐five consecutive paediatric intensive care unit (PICU) admissions were analysed. multiple organ dysfunction syndrome was defined as simultaneous dysfunction of ≥ 2 organ system and sepsis by the American College of Chest Physicians and Society of Critical Care Medicine Consensus Conference definition. Results: Eighty‐four patients developed MODS. The incidence of sepsis, severe sepsis and septic shock in these patients was 10.7%, 23.8% and 17.9%, respectively. Worsening categories of sepsis were associated with: (1) a higher mean admission Paediatric Risk of Mortality (PRISM II): 36.6 ± 25.9, 56.8 ± 32.1 and 73.6 ± 28.5%, respectively ( P = 0.005), (2) a larger number of organ dysfunctions: mean MODS index of 37%, 46% and 58%, respectively ( P = 0.007), and (3) a higher mortality: 22.2%, 65% and 80%, respectively ( P = 0.03). Conclusion: Presence of sepsis, severe sepsis and septic shock was associated with an increasing severity of illness, increased number of organ dysfunctions and a distinct risk of mortality among critically ill children.