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Elevated creatinine after ingestion of model aviation fuel: Interference with the Jaffe reaction by nitromethane
Author(s) -
Booth CJ,
Naidoo D,
Rosenberg AR,
Kainer G
Publication year - 1999
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.1999.355402.x
Subject(s) - medicine , nitromethane , ingestion , creatinine , poison control , aviation , medical emergency , emergency medicine , anesthesia , aerospace engineering , thermodynamics , physics , engineering
A 2 years 9 month‐old‐boy who ingested model aviation fuel was found to have an elevated serum creatinine concentration of 0.53 mmol/L (normal range 0.02–0.05 mmol/L) by the Jaffe (alkaline picrate) reaction. However, when the creatinine concentration was measured using a specific enzymatic assay, it was within the normal range. It was shown that nitromethane, a constituent of aviation fuel, interferes with the Jaffe reaction, leading to a falsely elevated creatinine reading. This phenomenon has been reported only once previously and, despite its potential clinical importance, nitromethane does not appear in published lists of substances that interfere with the Jaffe reaction.