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Efficacy and safety of oral desmopressin in the treatment of primary nocturnal enuresis in Asian children
Author(s) -
YAP HK,
CHAO SM,
TAN AYS,
MURUGASU B,
ONG EK,
LOW EH
Publication year - 1998
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1046/j.1440-1754.1998.00189.x
Subject(s) - medicine , enuresis , desmopressin , placebo , nocturnal , urine osmolality , randomized controlled trial , antidiuretic , pediatrics , adverse effect , anesthesia , clinical trial , urine , vasopressin , alternative medicine , pathology
Objective: To determine the efficacy and safety of oral desmopressin (DDAVP) treatment in Asian children with nocturnal enuresis. Methodology: This was a multicentre randomized placebo‐controlled double‐blind cross‐over study. Patients were randomized to either active treatment with oral 400 mg DDAVP or placebo, with a 2‐week medication‐free period between the cross‐over. Children with primary monosymptomatic nocturnal enuresis, aged between 7 and 18 years, with a minimum frequency of wetting of 6 nights or more during a 2‐week observation period were recruited. Efficacy was measured by reduction in the average number of wet nights per week. Results: Of the 37 children initially recruited, the outcomes for 34 children were included in the final cross‐over analysis, as they had complete data for both the treatment periods. Statistical analysis by anova showed that there was no significant difference between the medication‐free period and the pretreatment period. However, the average number of wet nights per week for the DDAVP treatment period (2.5±2.7) was significantly lower than that of the placebo treatment period (4.5±2.1) ( P <0.0001). In terms of the safety profile, there was no significant change in bodyweight, blood pressure, serum sodium, serum osmolality, and urine osmolality following DDAVP treatment. Conclusion: Oral DDAVP is a safe and efficacious drug for the short‐term treatment of children with primary nocturnal enuresis.