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Symptom relief in patients with reflux esophagitis: Comparative study of omeprazole, lansoprazole, and rabeprazole
Author(s) -
ADACHI KYOICHI,
HASHIMOTO TOMOYUKI,
HAMAMOTO NAOHARU,
HIRAKAWA KAZUYA,
NIIGAKI MASATOSHI,
MIYAKE TATSUYA,
TANIURA HIROYUKI,
ONO MASAHIRO,
KAJI TAKEKAZU,
SUETSUGU HIROSHI,
YAGI JUNKO,
KOMAZAWA YOSHINORI,
MIHARA TAKAFUMI,
KATSUBE TOMOKO,
FUJISHIRO HIROFUMI,
SHIZUKU TOSHIHIRO,
HATTORI SHUZO,
YAMAMOTO SHUN,
KINOSHITA YOSHIKAZU
Publication year - 2003
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2003.03190.x
Subject(s) - lansoprazole , heartburn , rabeprazole , omeprazole , medicine , gastroenterology , reflux esophagitis , proton pump inhibitor , reflux , esophagitis , disease
Background and Aim: Rabeprazole has a faster onset of antisecretory activity than omeprazole and lansoprazole. The aim of the present study was to clarify whether there is any difference in the speed of symptom relief in patients with reflux esophagitis following the administration of these three proton pump inhibitors (PPI). Methods: Eighty‐five patients with erosive reflux esophagitis were randomized to receive 8 weeks of 20 mg of omeprazole ( n = 30), 30 mg of lansoprazole ( n = 25), or 20 mg of rabeprazole ( n = 30) once a morning. Daily changes in heartburn and acid reflux symptoms in the first 7 days of administration were assessed using a six‐point scale (0: none, 1: mild, 2: mild–moderate, 3: moderate, 4: moderate–severe, 5: severe). Results: The mean heartburn score in patients administered rabeprazole decreased more rapidly than those given the other PPI. Complete heartburn remission also occurred more rapidly in patients administered rabeprazole (compared with omeprazole: P = 0.035, compared with lansoprazole: P = 0.038 by log‐rank test). No differences were seen in the rate of endoscopic healing of reflux esophagitis at 8 weeks between the three treatment regimens. Conclusion: Rabeprazole may be more effective than omeprazole and lansoprazole for the rapid relief of heartburn symptoms in patients with reflux esophagitis.