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Long‐term follow up of gastric low‐grade mucosa‐associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe
Author(s) -
YEH HONGZEN,
CHEN GRANHUM,
CHANG WENDAU,
POON SEKKWONG,
YANG SHENGSHUN,
LIEN HANCHUNG,
CHANG CHISEN,
CHOU GUAN
Publication year - 2003
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2003.02938.x
Subject(s) - medicine , submucosa , malt lymphoma , endoscopic ultrasound , helicobacter pylori , lymphoma , lymphatic system , gastric lymphoma , ultrasound , gastroenterology , radiology , stomach , stage (stratigraphy) , mucosa associated lymphoid tissue , gastric mucosa , pathology , paleontology , biology
Background and Aims: Endoscopic ultrasonography (EUS) is a useful tool for the evaluation of gastric wall infiltration including gastric lymphoma. The aims of this study were to characterize gastric low‐grade mucosa‐associated lymphoid tissue (MALT) lymphoma according to EUS findings and to evaluate the role of a miniature ultrasound probe in the long‐term follow up. Methods: From January 1994 to March 2002, 20 patients were proven to have gastric low‐grade MALT lymphoma. Endoscopic ultrasonography was performed with a conventional echoprobe and/or a miniature ultrasound probe for initial staging and a miniature ultrasound probe was performed during follow up. All patients positive for Helicobacter pylori received a 2‐week course of omeprazole, amoxicillin and clarithromycin. Results: Helicobacter pylori infection was found in 17 (85%) patients. In all patients, H. pylori was eradicated after treatment. Initial EUS showed significantly greater wall thickness (6.1 ± 3.0 mm) in MALT lymphoma patients when compared with control (2.8 ± 0.3 mm). The infiltrative patterns included wall thickening (3.5–14.1 mm) in 18 patients: stage E‐I 1 in 16 (mucosa and/or submucosa), stage E‐I 2 in one and stage E‐II in one. Complete regression of MALT lymphoma following treatment for H. pylori was noted in 14 patients, with a mean duration of 11.3 ± 9.1 months. Follow‐up miniature ultrasound probe sonography showed comparative reduction in wall thickness ( P < 0.05). Conclusions: Endoscopic ultrasonography plays a valuable role in the initial staging and long‐term follow up of gastric low‐grade MALT lymphoma. The application of a miniature ultrasound probe enables adequate evaluation in the majority of these patients, with additional benefits.