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Liver cirrhosis developed after ketoconazole‐induced acute hepatic injury
Author(s) -
KIM TAEHYUNG,
KIM BYUNGHO,
KIM YOUNWHA,
YANG DAL MO,
HAN YOSEB,
DONG SEOK HO,
KIM HYO JONG,
CHANG YOUNGWOON,
LEE JOUNG IL,
CHANG RIN
Publication year - 2003
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2003.02852.x
Subject(s) - medicine , ketoconazole , jaundice , cirrhosis , liver injury , gastroenterology , sequela , hepatitis , liver function tests , liver biopsy , surgery , biopsy , dermatology , antifungal
We describe a previously healthy woman who developed liver cirrhosis as a sequela of acute hepatic injury that was induced by ketoconazole administration to treat onychomycosis. The initial presentation of the disease was of a typical acute hepatitis, characterized by nausea, anorexia, fatigue, and jaundice that developed during the administration of ketoconazole. Many other causes of hepatitis were absent in the patient. Even though the hepatic injury was gradually resolved for several months after cessation of the drug, the liver function was not completely restored. Six months after the onset of illness, a follow‐up abdominal computed tomography and peritoneoscopic liver biopsy were performed. They revealed a marked reduction in the liver volume and a definite cirrhotic change, which persisted for more than 5 years. The case suggests that the administration of ketoconazole can cause liver cirrhosis through acute hepatic injury within a short time under certain circumstances.