Premium
Reflux esophagitis facilitates low Helicobacter pylori infection rate and gastric inflammation
Author(s) -
Jang Tae Jung,
Kim Nam Il,
Suh Jeong Ill,
Yang Chang Heon
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2002.02827.x
Subject(s) - reflux esophagitis , gastroenterology , medicine , helicobacter pylori , esophagitis , reflux , gastritis , rapid urease test , gerd , atrophic gastritis , incidence (geometry) , disease , physics , optics
Background: Helicobacter pyloriis regarded as an important pathogen in upper gastrointestinal diseases. However, little is known about the relationship betweenH. pyloriinfection and reflux esophagitis. Therefore, an investigation was undertaken in Korean subjects regarding the incidence ofH. pylori infection, and a histopathological study of reflux esophagitis was also carried out. Methods: Analysis of gastric biopsy specimens was conducted for 73 patients with reflux esophagitis and 132 control subjects without reflux esophagitis. The H. pylori infection was assessed by using rapid urease test and the immunohistochemical method, and gastric mucosal morphologic change was analyzed according to the updated Sydney system. Results: The prevalence of H. pylori infection was significantly lower in patients with reflux esophagitis than in the non‐reflux group. Grade of inflammation and glandular atrophy in the antrum and body were higher in patients in the non‐reflux group compared with those in the reflux esophagitis group. Conclusions: It is suggested that H. pylori infection decreases the risk of reflux esophagitis by inducing atrophic gastritis. © 2002 Blackwell Publishing Asia Pty Ltd