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Pyogenic liver abscess: Retrospective analysis of 80 cases over a 10‐year period
Author(s) -
Wong WaiMan,
Wong Benjamin Chun Yu,
Hui Chee Kin,
Ng Matthew,
Lai Kam Chuen,
Tso Wai Kuen,
Lam Shiu Kum,
Lai Ching Lung
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2002.02787.x
Subject(s) - medicine , pyogenic liver abscess , malignancy , chills , liver abscess , abscess , gastroenterology , retrospective cohort study , surgery , clinical pathology , elevated alkaline phosphatase , alkaline phosphatase , biochemistry , chemistry , enzyme
Background: A total of 80 patients with pyogenic liver abscess managed at a single institution over a 10‐year period were studied. Methods: The clinical features, laboratory, imaging, and microbiologic findings, management strategy, and final outcome were studied. Results: Fever and chills, leucocytosis and elevated alkaline phosphatase were the most common clinical and laboratory findings. Forty‐one percent of patients were diabetic and 61% had biliary pathology. Systemic antibiotics and image‐guided aspiration had a success rate of 94%. By multiple logistic regression analysis, malignancy on presentation ( P = 0.011) was an independent risk factor associated with mortality. A past history of endoscopic sphincterotomy was an independent factor associated with resolution of liver abscess within 6 weeks ( P = 0.03). Conclusion: Pyrexia, leucocytosis, elevated alkaline phosphatase, presence of diabetes, and underlying biliary pathology are common clinical and laboratory findings in patients with pyogenic liver abscess. Malignancy was associated with a poor outcome. Previous endoscopic sphincterotomy was a good prognostic factor for early resolution. © 2002 Blackwell Publishing Asia Pty Ltd