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Influences of Helicobacter pylori on gastric angiogenesis and ulcer healing in mice
Author(s) -
Gunawan Edhi,
Tsuji Shingo,
Tsujii Masahiko,
Kimura Arata,
Sun WeiHao,
Sawaoka Hitoshi,
Sasayama Yoshiaki,
Sasaki Yutaka,
Kawano Sunao,
Hori Masatsugu
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2002.02782.x
Subject(s) - angiogenesis , medicine , helicobacter pylori , wound healing , neovascularization , spirillaceae , gastroenterology , immunology , gastritis
Background and Aims: Helicobacter pyloriinfection is associated with peptic ulcers; however, it is unclear whether the bacterium delays ulcer healing. We investigated the influence ofH. pylorion ulcer healing in mice. We also examined the influence ofH. pylori infection on angiogenesis. Methods: An acetic acid ulcer was made in male BALB/c mice. Three days later (day 0), the animals were inoculated with H. pylori SS1 strain. The healing process of the ulcer was examined macroscopically and microscopically on days 0, 6 and 9. The index of angiogenesis was also determined using carmine dye injection. Results: On day 0, angiogenesis began at the ulcer margin while the mucosal epithelia had not yet regenerated. On days 6 and 9, angiogenesis and epithelial regeneration developed and ulcer size reduced. These phenomena were significantly suppressed in mice infected with H. pylori . Conclusion: Helicobacter pyloriinfection significantly suppressed angiogenesis and delayed ulcer healing. These results indicate thatH. pylori plays an important role in ulcer healing. © 2002 Blackwell Publishing Asia Pty Ltd