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An early cancer of the gastric cardia arising from carditis after long‐term gastroesophageal reflux disease in the absence of Helicobacter pylori infection
Author(s) -
Yagi Kazuyoshi,
Nakamura Atsuo,
Sekine Atsuo,
Oyamatsu Manabu,
Tamiya Yoichi,
Watanabe Hedenobu
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2002.02749.x
Subject(s) - medicine , carditis , helicobacter pylori , gastroenterology , gerd , intestinal metaplasia , cancer , esophagus , adenocarcinoma , metaplasia , reflux , gastritis , disease , pathology
We describe an early gastric cardiac cancer in a patient who had suffered long‐term gastroesophageal reflux disease (GERD) but showed no evidence of infection with Helicobacter pylori . Proximal gastrectomy and partial resection of the lower esophagus was performed. Histological examination revealed the lesion to be a gastric cardiac adenocarcinoma, which had partially invaded the submucosal layer. Intestinal metaplasia was also found in some areas. Inflammation, however, appeared to be limited to the gastric cardia. This cancer may have arisen via a sequence of carditis and cardiac intestinal metaplasia, due primarily to the GERD and not to H. pylori infection. © 2002 Blackwell Publishing Asia Pty Ltd