Premium
Different outcomes of vertical transmission of hepatitis C virus in a twin pregnancy
Author(s) -
INUI AYANO,
FUJISAWA TOMOO,
SOGO TSUYOSHI,
KOMATSU HARUKI,
ISOZAKI ATSUSHI,
SEKINE ISAO
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2002.02601.x
Subject(s) - medicine , transmission (telecommunications) , pregnancy , hepatitis c virus , obstetrics , virology , viral load , virus , vaginal delivery , pediatrics , genetics , biology , electrical engineering , engineering
The risk of vertical transmission of hepatitis C virus (HCV) from mother to infant has been well documented, but the exact mode of transmission is still unclear. In a set of monochorionic diamniotic monozygous twins, only the second baby was infected with HCV from the mother who was positive for serum HCV‐RNA. The babies had an uncomplicated vaginal delivery 3 min apart and they were both bottle fed from the outset. The second baby developed clinical hepatitis that persisted to 30 months follow up. The intrauterine environment should have been identical for these twins, and therefore, the maternal HCV factors, including viral load are not the sole determining factors for mother‐to‐infant transmission of HCV. © 2002 Blackwell Publishing Asia Pty Ltd