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Prevalence of functional dyspepsia and its relationship with Helicobacter pylori infection in a Japanese population
Author(s) -
Kawamura Akira,
Adachi Kyoichi,
Takashima Toshiharu,
Murao Mitsuyoshi,
Katsube Tomoko,
Yuki Mika,
Watanabe Makoto,
Kinoshita Yoshikazu
Publication year - 2001
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2001.02454.x
Subject(s) - medicine , helicobacter pylori , gastroenterology , helicobacter pylori infection , nausea , population , spirillaceae , helicobacter , gastritis , environmental health
Aim: To investigate the prevalence of functional dyspepsia and Helicobacter pylori infection and their relationship in a Japanese population. Methods: Two thousand five hundred people who visited Shimane Institute of Health Science for their annual medical check‐up from September 1998 to August 1999 were prospectively enrolled in the study. After routine medical examination, including an upper gastrointestinal study and an ultrasonographic examination, all subjects were asked standard questions to check for the presence of any symptoms that suggested dyspepsia. Helicobacter pylori infection was determined by using a serum IgG antibody concentration with an ELISA. Results: Of the 2500 persons investigated, 2263 showed no abnormal finding in any medical examination. The presence or absence of symptoms and H. pylori infection was investigated in these 2263 cases. Of these, 201 people (8.9%) experienced nausea, fullness and/or early satiety and were diagnosed as having dysmotility‐like dyspepsia, while 118 people (5.2%) experienced pain localized to the epigastrium and were diagnosed as having ulcer‐like dyspepsia. The frequency of these symptoms had a tendency to decline with age, although this was not statistically significant. In contrast, the rate of H. pylori infection increased with age. There was no significant relationship between H. pylori infection and any type of functional dyspepsia. Conclusions: Helicobacter pylori infection does not influence the prevalence of the dysmotility‐like and ulcer‐like dyspeptic symptoms.