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Comparison of the expression of ABH/Lewis‐related antigens in polypoid and non‐polypoid growth types of colorectal carcinoma
Author(s) -
Nakagoe Tohru,
Fukushima Kiyoyasu,
Nanashima Atsushi,
Sawai Terumitsu,
Tsuji Takashi,
Jibiki MasaAki,
Yamaguchi Hiroyuki,
Yasutake Toru,
Ayabe Hiroyoshi,
Matuo Tatsuki,
Tagawa Yutaka
Publication year - 2001
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2001.02425.x
Subject(s) - medicine , colorectal cancer , immunohistochemistry , antigen , monoclonal antibody , isoantigens , pathology , cancer , gastroenterology , antibody , immunology
Background and Aims: Colorectal tumors can be classified based on their growth pattern into the polypoid growth‐type (PG‐type) and non‐polypoid growth‐type (NPG‐type). To ascertain whether there is any relationship between the expression of particular blood group‐related antigens (A, B, H, Lewis (Le) a , sialyl Le a , Le x , sialyl Le x ) in a colorectal tumor, and a tumor having polypoid or non‐polypoid growth, we examined 78 PG‐type and NPG‐type colorectal cancers. Methods: Fourteen PG‐type and 64 NPG‐type colorectal carcinomas were subjected to immunohistochemical analyses by using monoclonal antibodies against A, B, H, Le a , sialyl Le a , Le x and sialyl Le x . Results: The patients with NPG‐type carcinomas had a significantly younger age of onset, significantly smaller maximal tumor diameter, significantly higher rate of lymph node metastasis and significantly worse prognosis than those with PG‐type carcinomas. Among the 32 tumors of patients with blood type A or AB, isoantigen A was expressed in a significantly larger percentage of NPG‐type carcinomas than PG‐type carcinomas (95.8 vs 62.5%, respectively; P = 0.014). Among all 78 tumors, sialyl Le x antigen was expressed in a significantly larger percentage of NPG‐type than PG‐type carcinomas (90.6 vs 64.3%, respectively; P = 0.010). Multivariate analysis using the logistic regression model revealed that isoantigen A and sialyl Le x expression were independent predictive risk factors for the development of NPG‐type colorectal carcinoma. Conclusions: These data suggest that the expression of isoantigen A and sialyl Le x in a colorectal carcinoma partially determines whether the tumor will have polypoid or non‐polypoid growth.