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Autoimmune hepatitis with membranous glomerulonephritis
Author(s) -
Takahashi Kazuhiro,
Takasaki Satoko,
Morita Chie,
Hayashida Kazuhiro,
Matsui Mieko,
Tamechika Yoshio,
Ishibashi Hiromi
Publication year - 2001
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2001.02345.x
Subject(s) - medicine , autoimmune hepatitis , anti nuclear antibody , glomerulonephritis , pathology , hepatitis , proteinuria , edema , liver biopsy , biopsy , immunology , antibody , kidney , autoantibody
We report on a case of autoimmune hepatitis (AIH) associated with membranous glomerulonephritis. A 61‐year‐old woman was admitted because of peripheral edema, proteinuria and abnormal liver function test findings. A diagnosis of AIH was made on the basis of an elevation of aminotransferase and serum IgG levels, the presence of positive antinuclear antibody and the characteristic histological features of chronic active hepatitis. Histological examination of a renal biopsy specimen disclosed membranous glomerulonephritis with granular deposits of IgG, IgM, C3 and C1q along the capillary walls. This condition is rare in AIH and should be carefully distinguished from systemic lupus erythematosus.