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Ranitidine‐related Stevens–Johnson syndrome in patients with severe liver diseases: A report of two cases
Author(s) -
Lin ChenChun,
Wu JawChing,
Huang DeFeng,
Huang YiShin,
Huang YiHsiang,
Huo TehIa,
Chang FullYoung,
Lee ShouDong
Publication year - 2001
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2001.02338.x
Subject(s) - ranitidine , medicine , jaundice , cirrhosis , gastroenterology , hepatitis , hepatocellular carcinoma , liver disease , ketoconazole , dermatology , cholestasis , drug , pharmacology , antifungal
Ranitidine is widely used and well tolerated. Ranitidine‐related skin eruption is rare and usually mild. We presented two patients who developed Stevens–Johnson syndrome after ranitidine therapy. Before therapy, both patients had severe liver disease and jaundice. The first was a case of ketoconazole‐induced hepatitis, and the second was a case of hepatitis C‐related liver cirrhosis with hepatocellular carcinoma. Ranitidine was the most likely drug responsible for causing Stevens–Johnson syndrome in these two patients.