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A short‐term eradication therapy for Helicobacter pylori acute gastritis
Author(s) -
Nomura Hideyuki,
Miyake Katsuhisa,
Kashiwagi Seizaburo,
Sugiyama Toshiro,
Asaka Masahiro
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02228.x
Subject(s) - medicine , lansoprazole , helicobacter pylori , gastroenterology , gastritis , clarithromycin , amoxicillin , antibiotics , microbiology and biotechnology , biology
Background and Aims Acute gastritis, caused by an initial infection of Helicobacter pylori ( H. pylori ), may resolve spontaneously, but the infection sometimes becomes chronic. We examined the efficacy of a short‐term H. pylori eradication therapy on acute gastritis. Methods Among the 15 patients with hemorrhagic acute gastritis who were randomly allocated to group A (eradication therapy) or group B (Lansoprazole, LPZ), 10 of them started to receive treatment within 1 day after the disease onset. The other five patients began the eradication therapy 4–6 days after disease onset (group C). Eradication therapy consisted of a daily oral administration of each of 30 mg lansoprazole (LPZ), once a day; 400 mg clarithromycin, twice a day; 1000 mg amoxicillin, twice a day; and 300 mg rebamipide, three times a day, for one week. If the endoscopy was normal, medication was stopped for the following 4 weeks before gastric endoscopy was performed again in order to assess H. pylori eradication. Results All group A patients were cured after the 1‐week treatment and therefore, they became H. pylori negative. Group B and C patients had erosions or ulcers after the 1‐week treatment and so received an additional 3‐week administration of LPZ. Four weeks later, their gastritis was cured and except for one group B patient, they became H. pylori ‐negative. Conclusion In patients with acute gastritis, caused by an initial H. pylori infection, eradication therapy was efficacious in achieving early healing. This therapy should be started as soon as possible after disease onset.