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Parathyroid hormone‐related peptide producing cholangiocellular carcinoma with a marked psammoma formation
Author(s) -
Yamada Shinwa,
Sanefuji Hayato,
Morimoto Hiroaki,
Harada Yuji,
Mine Shinichiro,
Morimoto Isao,
Eto Sumiya
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02222.x
Subject(s) - psammoma body , medicine , pathology , calcification , parathyroid hormone , abdominal ultrasonography , immunohistochemistry , radiology , calcium , ultrasonography
Humoral hypercalcemia caused by parathyroid hormone‐related peptide (PTHrP), associated with cholangiocellular carcinoma (CCC), has rarely been documented. There have been no reports of CCC associated with extensive calcification of the tumor with psammoma body formation. A 66‐year‐old man was admitted with a large calcified tumor in the liver detected on an abdominal X‐ray. An ultrasound‐guided fine needle biopsy specimen of the liver tumor showed evidence of adenocarcinoma. He had hypercalcemia with an elevated PTHrP level. The patient died because of disseminated intravascular coagulation and progressive hepatic failure. A postmortem examination revealed a large poorly differentiated CCC in the liver. Immunohistochemical examination showed the presence of PTHrP‐positive tumor cells. The calcified lesion consisted of a number of accumulated psammoma bodies. We present a case of PTHrP producing CCC with a marked psammoma formation.