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Rapid urease test is less sensitive than histology in diagnosing Helicobacter pylori infection in patients with non‐variceal upper gastrointestinal bleeding
Author(s) -
Archimandritis Athanasios,
Tzivras Michael,
Sougioultzis Stavros,
Papaparaskevas Iosif,
Apostolopoulos Periklis,
Avlami Athina,
Davaris Panagiotis S
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02171.x
Subject(s) - medicine , rapid urease test , gastroenterology , helicobacter pylori , histology , gastritis , endoscopy , spirillaceae , gastrointestinal bleeding , proton pump inhibitor , upper gastrointestinal bleeding
Background and Aims: The validity of the rapid urease (CLO) test to diagnose Helicobacter pylori infection in patients with bleeding ulcers has been questioned. The aim of this paper is to evaluate the validity of the CLO test in comparison with histology in diagnosing H. pylori infection in patients with acute upper gastrointestinal bleeding (UGB), irrespective of non‐steroidal anti‐inflammatory drug (NSAID) use.Methods: Upper gastrointestinal endoscopy was performed within 24 h of admission for all patients with UGB admitted to the Department of Pathophysiology, Medical School, Athens, for a period of 12 months. Patients with variceal bleeding, previous gastric operation, recent treatment with proton pump inhibitors (< 2 months) and those with a history of H. pylori eradication therapy were excluded from the study. At least four biopsies (two from the antrum and two from the body) were obtained for the CLO test and histology (modified Giemsa).Results: Seventy‐two consecutive patients (aged 18–90 years, 51 men, 21 women) were included. Forty‐six patients (64%) used NSAID. Thirty‐two patients (44%) were found to be positive for H. pylori infection by the CLO test, while 44 patients (61%) were found to be positive on histology ( P < 0.045, 95% CI, 0.004–0.331). The sensitivity and specificity of the CLO test were 68 and 93% respectively; positive and negative predictive values were 94 and 65%, respectively. The age of the patient and visible blood in the stomach did not inflence results of either the CLO or histology.Conclusions: The CLO test, performed within 24 h of hospital admission in patients with UGB, irrespective of NSAID use, is unreliable for the detection of H. pylori infection. The age of the patient and the presence of blood in the stomach do not seem to influence these results.