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A 15 ‐ minute [ 13 C]‐urea breath test for the diagnosis of Helicobacter pylori infection in patients with non‐ulcer dyspepsia
Author(s) -
Peng NanJing,
Hsu PingI,
Lee ShuiCheng,
Tseng HueiHwa,
Huang WenKeui,
Tsay DawGuey,
Ger LuPing,
Lo GinHo,
Lin ChiunKu,
Tsai ChiChang,
Lai KwokHung
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02159.x
Subject(s) - medicine , gold standard (test) , breath test , gastroenterology , helicobacter pylori , rapid urease test , urea breath test , spirillaceae , endoscopy , helicobacter pylori infection , gastritis
Background: Non‐ulcer dyspepsia (NUD) accounts for the majority of dyspeptic patients and studies on the epidemiology of Helicobacter pylori infection in NUD depend on a non‐invasive and rapid diagnostic test. This study was performed to determine the sensitivity and specificity of a 15‐min simplified protocol of the [ 13 C]‐urea breath test ([ 13 C]‐UBT) for the diagnosis of H. pylori infection in patients with NUD.Methods: One hundred and thirty‐six patients with a clinical and endoscopic diagnosis of NUD were included. The [ 13 C]‐UBT was modified from the European standard protocol. The baseline breath sample was collected 5 min after the patient took a test meal and the 13 CO 2 was collected 15 min after the patient drank 100 mg [ 13 C]‐urea. The gold standard used for comparison was either a positive culture or positive histology + positive rapid urease test sampled on upper gastrointestinal endoscopy.Results: The prevalence of H. pylori infection in NUD by the gold standard was 59.6%, whereas that calculated by the [ 13 C]‐UBT was 60.3%. The sensitivity and specificity of [ 13 C]‐UBT was 93.8 and 89.1% compared with the gold standard. The shortened collection time and simplification of the procedure may have led to a decline in specificity.Conclusion: The 15‐min [ 13 C]‐UBT is a rapid but less specific protocol for detecting the presence of H . pylori infection in patients with NUD. © 2000 Blackwell Science Asia Pty Ltd