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Effect of age and Helicobacter pylori infection on gastric acid secretion
Author(s) -
Haruma Ken,
Kamada Tomoari,
Kawaguchi Hiroyuki,
Okamoto Shiro,
Yoshihara Masaharu,
Sumii Koji,
Inoue Masaki,
Kishimoto Shinya,
Kajiyama Goro,
Miyoshi Akima
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02131.x
Subject(s) - medicine , helicobacter pylori , secretion , gastric acid , gastric secretion , gastroenterology , spirillaceae , helicobacter infections , helicobacter pylori infection , stomach , gastritis
Background: Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori , the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and H. pylori infection.Methods: The presence of H. pylori infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. Helicobacter pylori infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0–4.Results: Both basal and maximal acid output decreased with age in H. pylori ‐positive subjects, while they did not change with age in H. pylori ‐negative subjects. Gastric acid secretion decreased with the progression of FAG. An age‐correlated decrease in gastric acid secretion in H. pylori ‐positive subjects depended on an increasing prevalence of FAG with age.Conclusions: In the population studied, advancing age had no influence on gastric acid secretion in H. pylori ‐negative subjects. Gastric acid secretion decreases with age in H. pylori ‐positive subjects because of the increasing prevalence of FAG with age. © 2000 Blackwell Science Asia Pty Ltd