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HISTOLOGICAL DEGREE IN HELICOBACTER PYLORI GASTRITIS IN RELATION TO THE ABSENCE OR PRESENCE OF BILE REFLUX
Author(s) -
Rani Abdul Aziz
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.00a60.x
Subject(s) - bile reflux , medicine , gastroenterology , intestinal metaplasia , helicobacter pylori , gastritis , gastric mucosa , chronic gastritis , reflux , biopsy , metaplasia , antrum , helicobacter , stomach , pathology , disease
Background: the presence of Helicobacter pylori (Hp) in gastric mucosa could be influenced by bile reflux. Aims: to compare the histological parameters of gastric mucosal biopsies in bile reflux positive and bile reflux negative among the Hp gastritis. Methods: One hundred and forty four patients (M=73, F=71) with Hp gastritis from the private hospital in Jakarta were enrolled in this study. Two biopsy specimens (antrum and corpus of gaster) were taken from all consecutive patients during the period of January 1998 to December 1999. The grade of gastritis was examined according to the Sydney System (chronic inflammation, neutrophillic infiltration, glandular atrophy and intestinal metaplasia). Presence of Hp infection was determined by histology. A single senior Pathologist did all histopathological assessment. Bile reflux was defined as an evidence of significant amount of bile in gastric lumen with or without hyperemia and/or erosion on gastric mucosa. The presence of raptor during the procedure was an exclusion criteria. Result: twelve (M=4, F=8) out of 144 were positive for bile reflux. Comparison of the average scores of the different histologic features of the biopsy specimens among those with bile reflux and without bile reflux showed that chronic inflammation, neutrophillic infiltration, glandular atrophy and intestinal metaplasia was statistically not significant. Conclusion: chronic gastritis induced by Hp, suggestively not related to the absence or presence of bile reflux