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CagA NEGATIVE STATUS IS ASSOCIATED WITH A HIGH RATE OF RECURRENCE OF H. PYLORI FOLLOWING ERADICATION IN INDIAN PATIENTS WITH DUODENAL ULCER
Author(s) -
Ahuja Vineet,
Arur Swathi,
Kumar Dinesh,
Sharma. M.p
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.00a42.x
Subject(s) - medicine , gastroenterology , helicobacter pylori , rapid urease test , endoscopy , urea breath test , duodenal ulcer , surgery , helicobacter pylori infection
Background and Aim High prevalence of H. pylori (Hp) in developing countries may result in high reinfection rates. The study was aimed to determined the reinfection rate and duodenal ulcer (DU) reccurence and to determine whether they correlated with Cag A status of Hp isolates. Methods 106 patients with DU proven by endoscopy and who were positive for Hp (rapid urease test C‐14 urea breath test, and culture) were given triple therapy for Hp eradication. Patients were followed post eradication at 3 months and then every 6 month with endoscopy and tests for Hp. Cag A positivity was determined by polymerase chain reaction. Results 106 patients had a mean follow up of 15.3 month (3‐48 months). 74 (70%) of the 106 patients were found to be Hp negative after therapy. 19 (26%) of these 74 patients were againt found to be Hp positive with a recurrence rate of 14.6% per year. Duodenal ulcer recurred in 14 of these 19 patients (73.6%) and in none of 55 non reinfected patients. Cag A status was determined in 44 patients. Of the 33 patients in which Cag A was negative ulcer recurred in 5 (45.5%) patients. (p value < 0.07). Conclusion There was a high rate of recurrence of H. pylori and duodenal ulcer following Hp eradication. Cag A negative status in Hp isolates is associated with a higher rate of recurrence.