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HELICOBACTER PYLORI INFECTION AND THE DEGREE OF GASTRITIS IN PATIENTS WITH OSTEOARTHRITIS TREATED WITH SODIUM DICLOFENAC
Author(s) -
Syukri Maimun,
Oesman Nizam,
Kusumobroto Hernomo O,
Adi Pangestu,
Soeroso Joewono,
Soemarno Troef
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.00a28.x
Subject(s) - medicine , gastroenterology , gastritis , helicobacter pylori , diclofenac , intestinal metaplasia , chronic gastritis , rapid urease test , diclofenac sodium , atrophic gastritis , duodenitis , pharmacology
The use of Non‐Steroid Anti Inflammation Drugs (NSAIDs) and Helicobacter Pylori (H. pylori) infection increase the risk of peptic ulcer and gastropathy, but the association between H. pylori and NSAIDs in developing gastro‐duodenal lesion remains unclear Objective To evaluate whether H. pylori infection increases the degree of gastritis in osteoarthritis patients treated with oral Sodium diclofenac. Material and methods Twenty eight patients with osteoarthritis who took Sodium diclofenac orally for more than 4 weeks in the Division of Rheumatology Dr. Soetomo Hospital ‐ Surabaya participated in this cross‐sectional study. The endoscopic evaluation was conducted in the Division of Gastroenterology in the same hospital, and the results were graded using Modified Gastroscopy Rating Scale of Lanza. Antral and gastric body biopsies were stained with Giemsa and Warthin‐Starry methods. The Sydney System was used to descibe chronic gastritis, metaplasia, gastric atrophy and H. pylori infection. The result was analyzed using Chi‐square test and any (p)=0.05 was considered significant. Result On endoscopic evaluation 11 (39.29%) patients had normal gastric mucosa, 5 (17.86%) patients showed 1 location of erosion while the rest 12 (42.85%) patients had more than 1 location of erosion or bleeding. H. pylori was found on 16 (57.14%) patients. Twelve (57.14%) patients out of 21 patients with dyspepsia were positive for H. pylori. H. pylori was positively identified on 9 (75%) patients with superficial chronic gastritis, 4 (50%) patients with acute gastritis, 1 (100%) patient with chronic gastritis and metaplasia, and on 2 (28.57%) patients with chronic gastritis and atrophy. When the 16 patients infected with H. pylori were graded with Lanza Scale, 7 (43.75%) patients were in grade 0.4 (25%) patients in grade 1, and the other 5 (31.25%) patients were in grade 2. On statistical analysis, we did not find any significant association between H. pylori infection and the degree of gastritis in osteoarthritis patients taking Sodium diclofenac. Conclusion We found that H. pylori infection did not increase gastritis degree in osteoarthritis patients who took oral Sodium diclofenac.