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EFFICACY OF SERUM PEPSINOGENS IN THE PREDICTION OF ENDOSCOPIC FEATURES OF GASTRITIS
Author(s) -
Urita Yoshihisa,
Torii Naotaka,
Hike Kazuo,
Sasajima Masahiko,
Kanda Eiko,
Matsuzaki Hiroshi,
Miki Kazumasa
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.000a3.x
Subject(s) - medicine , gastroenterology , intestinal metaplasia , pepsin , antrum , gastritis , endoscopy , cancer , breath test , gastric mucosa , helicobacter pylori , stomach , biochemistry , biology , enzyme
Objective The efficacy of serum pepsinogen (PG) test is widely accepted as a screening test to select persons for endoscopy in the diagnosis of gastric cancer. In this study, we would like to examine whether serum PG levels give us information on endoscopic findings of gastric mucosa. Materials and methods The serum level of PG++ and PG+− and the PG+/PG− ratio were compared with endoscopic 13C‐urea breath. H.pylori status was defined as an increase in the intragastric 13CO 2 /12CO 2 ratio of 10% over baseline. Intestinal metaplasia was made visible as the purple‐stained area using a 0.05% crystal violet spraying method. PG level of less than 70μg/L and I PG+/PG− ratio of less than 3 was adopted for a (+) result, and PG level of less than 30μg/L and a PG+/PG− ratio of less than 2 for a (++) result. Results Prevalence of endoscopic features and H. pylori infection in different groups classified by serum PG tests. Conclusions Lintestinal metaplasia was identified in more than 80% of PG positive patients. The prevalence of linear reddness and raised erosion in the antrum were higher in PG (‐) group than in PG(+) and (++) groups. H. pylori‐positive rate was the highest in PG (+) group.