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C ASE R EPORT : Occurrence of hepatocellular carcinoma 4.5 years after successful treatment with virus clearance for chronic hepatitis C
Author(s) -
Miyano Shintaro,
Togashi Hitoshi,
Shinzawa Haruhide,
Sugahara Kazuhiko,
Matsuo Taku,
Takeda Yoshio,
Saito Koji,
Saito Takafumi,
Ishiyama Shuichi,
Kaneko Masayuki,
Takahashi Tsuneo
Publication year - 1999
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.1999.01954.x
Subject(s) - hepatocellular carcinoma , medicine , interferon , hepatitis c virus , virus , alpha interferon , interferon alfa , hepatitis , recombinant dna , virology , carcinoma , hepatitis c , gastroenterology , immunology , pathology , biology , biochemistry , gene
A 67‐year‐old man with hepatitis C virus infection and histological features of chronic active hepatitis was treated with human recombinant interferon alpha‐2b. He responded successfully to interferon with normalization of serum alanine aminotransferase and continuous eradication of hepatitis C virus. However, 4.5 years after the end of interferon therapy, hepatocellular carcinoma, 20 mm in diameter, was detected by routine ultrasonographic screening. The patient underwent surgical treatment for resection of the hepatocellular carcinoma. The non‐cancerous liver tissue was histologically normal. This suggests that patients who have shown a complete response to interferon therapy for chronic hepatitis C should be followed up closely.