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Prevalence of TT virus before and after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma
Author(s) -
Kobayashi Masahiro,
Chayama Kazuaki,
Arase Yasuji,
Kobayashi Mizuho,
Tsubota Akihito,
Suzuki Yoshiyuki,
Koida Isao,
Saitoh Satoshi,
Murashima Naoya,
Ikeda Kenji,
Koike Hiromi,
Hashimoto Michie,
Kobayashi Mariko
Publication year - 1999
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.1999.01860.x
Subject(s) - medicine , hepatocellular carcinoma , gastroenterology , blood transfusion , virus , chronic liver disease , fresh frozen plasma , liver disease , carcinoma , platelet , cirrhosis , immunology
Background : To examine the prevalence of TT virus (TTV) before and after blood transfusion, we retrospectively examined serum samples obtained from 55 patients who received blood transfusions before, during and after resection of hepatocellular carcinoma. Methods : TT virus DNA was extracted from serum samples and detected by nested polymerase chain reaction. Before transfusion, seven (12.7%) were positive for TTV. Patients were transfused whole blood or separated blood components (fresh frozen plasma, platelet and/or red blood cells), the total amount of transfused fresh frozen plasma ranging from 12 to 271 (median 38) units. Results : Seven (14.6%) of the 48 TTV‐negative patients became positive for TTV‐DNA 1 month after transfusion. Only one of the seven patients, who was already positive for HCV‐RNA, exhibited elevation of alanine aminotransferase. Five of the newly infected seven patients become negative for TTV during a 2 year follow up. Conclusions : Our findings suggest that the proportion of patients with TTV was relatively high in this sample, and that the prevalence of TTV transmission by blood components was also relatively high (14.6%). Although TTV persisted for more than 6 months in some patients, infection was not noticeable during the course of chronic liver disease.