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Evaluation of endoscopic variceal ligation in prophylactic therapy for bleeding of oesophageal varices: A prospective, controlled trial compared with endoscopic injection sclerotherapy
Author(s) -
Gotoh Yudai,
Iwakiri Ryuichi,
Sakata Yasushi,
Koyama Takanori,
Noda Takahiro,
Matsunaga Chika,
Ogata ShinIchi,
Ishibashi Sadatoshi,
Sakata Hiroyuki,
Tsunada Seiji,
Fujimoto Kazuma
Publication year - 1999
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.1999.01841.x
Subject(s) - medicine , sclerotherapy , varices , cirrhosis , varix , surgery , ligation , randomized controlled trial , endoscopy , portal hypertension , prospective cohort study , esophageal varices , gastroenterology
Background : To evaluate the efficacy of endoscopic variceal ligation (EVL) in prophylactic therapy for oesophageal varices, we performed a randomized prospective trial to compare the recurrence of oesophageal varices treated by EVL with those treated by endoscopic injection sclerotherapy. Methods : Fifty patients with liver cirrhosis were divided into two groups at random, after informed consents were obtained, to receive prophylactic therapy for bleeding of oesophageal varices. Group 1 patients underwent sessions of sclerotherapy with 5% ethanolamine oleate used as the sclerosant. Group 2 patients underwent EVL followed by one or two sessions of sclerotherapy. Results : During the 18 month follow‐up period, both the recurrence rate in group 2 (56%) and the incidence of bleeding (20%) were significantly higher compared with group 1 (recurrence rate 16%, bleeding 0%). Conclusions : This result indicates that EVL is not effective for prophylactic therapy for oesophageal varices in liver cirrhosis.