Premium
Etiopathogenesis of acute hepatic failure: Eastern versus Western countries
Author(s) -
ACHARYA SK,
BATRA Y,
HAZARI S,
CHOUDHURY V,
PANDA SK,
DATTAGUPTA S
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.17.s3.12.x
Subject(s) - medicine , occult , etiology , hepatitis b virus , liver failure , virus , acute hepatitis , hepatitis a virus , acute hepatic failure , chronic hepatitis , immunology , hepatitis , virology , pathology , alternative medicine
Etiopathogenesis of acute hepatic failure (AHF) in Eastern and Western countries is distinct. In the East hepatitis viruses cause AHF in more than 95% of such cases, while causes of AHF in the West are quite heterogenous. Hepatitis E virus is the major etiological agent of AHF in countries like India where the virus is hyperendemic. Occult HBV infection may also be causing AHF in a sizable proportion of cases in areas where chronic HBV infection frequency is high. Paracetamol causes AHF in about 70% cases in the UK and about 20% cases in USA, whereas in France and Denmark, non‐steroidal anti‐inflammatory drugs are more frequently associated with AHF. Hepatitis B virus causes AHF in about one‐third of cases in the latter two countries. © 2002 Blackwell Publishing Asia Pty Ltd